A Comprehensive Guide to Nephrotic Syndrome: Causes, Symptoms, and Treatment

nephrologist in Ludhiana

A Comprehensive Guide to Nephrotic Syndrome: Causes, Symptoms, and Treatment

  • October 13, 2023


Nephrotic Syndrome is a kidney disorder characterized by the presence of certain symptoms resulting from damage to the glomeruli, the tiny blood vessels in the kidneys responsible for filtering waste and excess fluids from the blood. This condition leads to abnormal levels of protein in the urine, low protein levels in the blood, edema (swelling), and elevated cholesterol levels. Understanding the causes, symptoms, and treatment options for Nephrotic Syndrome is essential for managing and improving the health of those affected. If you or a loved one are facing Nephrotic Syndrome, consulting with a nephrologist in Ludhiana or a healthcare professional is a crucial step in diagnosis and personalized treatment planning.


Nephrotic Syndrome can be caused by various underlying conditions that affect the kidneys’ filtration system, such as:

  1. Minimal Change Disease: This is the most common cause of Nephrotic Syndrome in children. The glomeruli appear normal under a microscope, but they don’t function properly.
  1. Focal Segmental Glomerulosclerosis (FSGS): In FSGS, certain segments of the glomeruli are scarred, leading to protein leakage and kidney damage.
  1. Membranous Nephropathy: This occurs when the glomeruli’s filters thicken, causing increased protein leakage.
  1. Diabetic Nephropathy: Uncontrolled diabetes can damage the kidneys’ blood vessels, leading to Nephrotic Syndrome.
  1. Systemic Lupus Erythematosus (SLE): An autoimmune disease that can cause inflammation in various organs, including the kidneys.



The primary symptoms of Nephrotic Syndrome include:

  1. Proteinuria: Excessive protein in the urine, leading to foamy or frothy urine.
  1. Edema: Swelling, especially around the eyes, hands, feet, and abdomen, due to fluid retention.
  1. Hypoalbuminemia: Low levels of protein (albumin) in the blood.
  1. Hyperlipidemia: Elevated levels of cholesterol and triglycerides in the blood.
  1. Fatigue: Due to anemia and general weakness caused by protein loss.


Treatment for Nephrotic Syndrome aims to control symptoms, manage underlying conditions, and prevent further kidney damage. The treatment plan may include:

  1. Corticosteroids: These anti-inflammatory medications are often the first line of treatment for Nephrotic Syndrome, especially in cases of minimal change disease and some other glomerular diseases.
  1. Immunosuppressive Drugs: In cases of immune-related Nephrotic Syndrome, medications that suppress the immune system, such as cyclophosphamide or mycophenolate mofetil, may be prescribed.
  1. Angiotensin-Converting Enzyme (ACE) Inhibitors or Angiotensin Receptor Blockers (ARBs): These medications help control blood pressure and reduce protein leakage.
  1. Diuretics: To help manage edema and reduce fluid retention.
  1. Low-Sodium Diet: Reducing salt intake can aid in controlling edema.
  1. Statins: Medications to manage elevated cholesterol levels.


Nephrotic Syndrome is a kidney disorder characterized by proteinuria, edema, and altered blood protein and lipid levels. Understanding the underlying causes and recognizing the symptoms is vital for early detection and appropriate management. With timely diagnosis and a comprehensive treatment plan, individuals with Nephrotic Syndrome can achieve symptom control, slow down disease progression, and improve their overall kidney health and quality of life. If you or someone you know is experiencing symptoms of Nephrotic Syndrome, it is essential to seek medical evaluation and guidance from a nephrologist in Ludhiana or a healthcare professional.